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Not Getting Affected By Weed

So i was wondering if its possible to not be affected by weed? I love smoking and its fine for me but i thought it would suck to not get the effects of THC. Is it possible to wake up one day and smoke a bowl but not feel anything? I know your tolerance builds up to points where you need to take tolerance breaks, but is it possible for something really weird like the cannabinoid receptors in your brain stop working? They stop reacting and you cant get high anymore? Just a weird thought i had on my mind and was wondering what other people thought.

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